Research Overview

My long-term research interest is to develop and apply computational approaches for studying transcriptional and epigenetic regulation. My group at Roswell Park Comprehensive Cancer Center focuses on building bioinformatics algorithms for single-cell genomics assays to study gene regulatory mechanisms and the influence of the genetic variations at cis-regulatory elements. I am maintaining some widely used bioinformatics algorithms for genomics analysis such as MACS for Chromatin Immunoprecipitation with High-throughput Sequencing. I have close collaborations with experimentalists, biologists and clinicians in various fields.