Tao Liu lab at Roswell Park

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Introduction

We are focusing on developing and applying computational approaches for studying transcriptional and epigenetics regulation in vairous models. We developed widely used open-source algorithms, including MACS (cited over 5,000 times according to Google Scholar) to analyze ChIP-seq data, and CistromeAP, an integrative platform for comprehensive analyses on cis-regulatory elements, which has over 3,000 users. The PI, Tao Liu, was a member of the Data Analysis Center and Analysis Working Group of the ENCODE and modENCODE consortium and was involved in deciphering functional elements through analyzing high-throughput profiles of chromatin factors and in comparing chromatin features between fly, worm and human genome. We have actively participated in the development of ChIP-seq guidelines for the broad scientific communities.